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Plasmid Design Services: Automated design of combinatorial libraries

Plasmid design services to automated design workflows using genetic parts libraries, design rules, and combinatorial design editors.

Plasmid Design Services

Derived from the GenoCAD application,  the design data automation services allow users to automate the design of plasmids online. They include several modules that work together to support structured workflows to design plasmids and optimize expression vectors.

Database of Genetic Parts

The parts database includes thousands of genetic parts used to develop plasmids for various applications. In particular, it includes the GenoLIB library with close to 2,000 genetic parts derived from the annotations of commonly used plasmids. It also includes iGEM library includes parts derived from the iGEM Registry. Other libraries include parts to design synthetic transcription factorsexpression vectors in plants or Chlamydomonas reinhardtii.

part management tool

 The plasmid design services include a module to manage collections of genetic parts.

Part Library Management

Dealing with so many parts can be overwhelming. Users can customize their workspace to add their own genetic parts and organize them in libraries. The design services streamline the process by allowing users to navigate large libraries of sequences, select the ones they want to use in their project, and organize them in libraries corresponding to a team or a project.

All the data can be exported using standard file formats.

 

Design Rule Editor

The design rule editor allows users to capture their expertise in vector design by defining rules describing how parts should be combined. Some rules are universal. All genes need to have a start and stop codon. Others are very specific of an organism or a type of project.

The design rule editor allows your team to think about the best way to design your constructs. It makes it possible to share these rules in your organization or with the scientific community.

design rule editor

Module to edit design rules using a drag and drop interface.

Plasmid Design – Sequence Editing

Users can design new sequences in few clicks by using parts in a library and the design rules set for the project. Many projects require the design of families of constructs to test different combinations of parts. The sequence editor supports the combinatorial design of families of constructs.

At the end of the design process, you can export your sequences using standard bioinformatics formats like GenBank or FASTA.

exporting dna designs

The combinatorial design tool makes it possible to export multiple constructs in standard formats.

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